PAPER: Management and Outcomes of Isolated Axillary Node Recurrence in Breast Cancer

Surgeon · 27-09-06, 02:22

Hypothesis* Management strategies affect the outcome of axillary recurrence in breast cancer.
Design* Population-based analysis.
Setting* Cancer agency breast cancer database.
Patients* Two hundred twenty women diagnosed with stage 0 through III breast cancer between 1989 and 2003 who subsequently developed an isolated axillary relapse.
Main Outcome Measures* Overall survival rate and disease-free survival rate according to treatment strategy of the axillary recurrence.
Results* Among 19*789 women diagnosed with stage 0 through III breast cancer during the study era, 220 had an isolated axillary recurrence (Kaplan-Meier 5-year isolated axillary relapse rate, 1.0%). The median interval between primary breast cancer diagnosis and axillary recurrence was 2.2 years (range,1.8 months to 11.9 years). Median follow-up time after axillary recurrence was 5.4 years. Treatment for the axillary recurrence included lymph node biopsy (47.3%), complete axillary dissection (25.9%), axillary radiation (65.0%), chemotherapy (24.1%), and hormonal therapy (68.2%). The 5-year Kaplan-Meier overall survival rate estimate after axillary recurrence was 49.3% (95% confidence interval, 42.0-56.3). Median survival time from the isolated axillary recurrence was 4.9 years (range, 2.0 months to 15.1 years). Overall (P

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27-09-06, 02:22	#1
Surgeon Official Forum News Anchor Join Date: Jan 2006 Posts: 4,264	PAPER: Management and Outcomes of Isolated Axillary Node Recurrence in Breast Cancer Hypothesis* Management strategies affect the outcome of axillary recurrence in breast cancer. Design* Population-based analysis. Setting* Cancer agency breast cancer database. Patients* Two hundred twenty women diagnosed with stage 0 through III breast cancer between 1989 and 2003 who subsequently developed an isolated axillary relapse. Main Outcome Measures* Overall survival rate and disease-free survival rate according to treatment strategy of the axillary recurrence. Results* Among 19789 women diagnosed with stage 0 through III breast cancer during the study era, 220 had an isolated axillary recurrence (Kaplan-Meier 5-year isolated axillary relapse rate, 1.0%). The median interval between primary breast cancer diagnosis and axillary recurrence was 2.2 years (range,1.8 months to 11.9 years). Median follow-up time after axillary recurrence was 5.4 years. Treatment for the axillary recurrence included lymph node biopsy (47.3%), complete axillary dissection (25.9%), axillary radiation (65.0%), chemotherapy (24.1%), and hormonal therapy (68.2%). The 5-year Kaplan-Meier overall survival rate estimate after axillary recurrence was 49.3% (95% confidence interval, 42.0-56.3). Median survival time from the isolated axillary recurrence was 4.9 years (range, 2.0 months to 15.1 years). Overall (P Read the full article at Archives of Surgery*
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