P450 Inducers and Inhibitors

DrIreland · 27-07-06, 09:29

Sometimes it's nice to just have a full list of all the important P450 Inducers and Inhibitors that includes the subunits...I had this dark feeling that not only could the Step 1 writers ask whether grapefruit juice inhibits or induces but at which subunit (is it 3A4 (troglitazone inducer) or 1A2 (macrolide inhibitor), so I made a couple of tables from Katzung and Trevor's pharmacology. A list more complete than first aid, daunting but complete!

doctor_b · 27-07-06, 09:44

Thanks Erik!

My list thus far (more eclectic than comprehensive):

Induce P-450: GTQ CRABS Griseofulvin, Tetracycline, Quinidine, Carbamazepine, Rifampin, Alcohol, Barbiturates, Sulfa drugs (e.g. TMP-SMX etc.)

Inhibit P-450: IQ SMACKD Isoniazid (a.k.a. INH), Quinolones, Spironolactones, Macrolides, Amiodarone, Cimetidine, Ketoconazole, Dapsone

P-450 Dependent: WEPTD Warfarin, oEstrogen, Phenytoin, Theophylline, Digoxin

peterz · 04-05-10, 09:38

Resveratrol, Quercetin, or Curcumin are now popular supplements, Any eveidence that they are p450 inhibitors?

thanks,

pete

27-07-06, 09:44	#2
doctor_b Gary Administrator Join Date: Jan 2006 Location: Dublin, Ireland Age: 31 Posts: 145	Thanks Erik! My list thus far (more eclectic than comprehensive): Induce P-450: GTQ CRABS Griseofulvin, Tetracycline, Quinidine, Carbamazepine, Rifampin, Alcohol, Barbiturates, Sulfa drugs (e.g. TMP-SMX etc.) Inhibit P-450: IQ SMACKD Isoniazid (a.k.a. INH), Quinolones, Spironolactones, Macrolides, Amiodarone, Cimetidine, Ketoconazole, Dapsone P-450 Dependent: WEPTD Warfarin, oEstrogen, Phenytoin, Theophylline, Digoxin
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04-05-10, 09:38	#3
peterz Junior Member Join Date: May 2010 Posts: 1	Resveratrol, Quercetin, or Curcumin as p450 inhibitors? Resveratrol, Quercetin, or Curcumin are now popular supplements, Any eveidence that they are p450 inhibitors? thanks, pete
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